SYK and neoplasm: Syk Inhibitors: In addition to its role in CLR signalling and antifungal immunity, Syk kinase is also involved in tumour biology, both as a tumour activator (in B-cell malignancies) and suppressor (in acute myeloid leukaemia and Epstein–Barr virus-derived tumours) through its ability to modulate apoptosis, cell migration and tumorigenesis, depending on cell type [55].