CXCR1 and candidiasis: These studies therefore indicate that CXCR1/2 inhibition could be a potential risk factor for the development of invasive candidiasis, and warrants the careful observation of patients on CXCR1/2 inhibitors for any signs of disseminated fungal infection [53], especially since CXCR1/2 are thought to play other non-conventional roles in immunity, including cell survival, proliferation and differentiation [53].