In patients and mice deficient in CARD9, defective production of CXCR1/2 ligands in the brain leads to decreased neutrophil trafficking and an unchallenged invasive fungal infection in the CNS [54], further underscoring the importance of CXCR1/2 signalling in the control of systemic C. albicans infections. The gene discussed is CARD9; the disease is fungal infectious disease.