In general, cyclohexanone is a common scaffold in various bioactive heterocycles of medicinal interests, particularly those used for the treatment of asthma and central nervous system (CNS)- and chronic obstructive pulmonary diseases (COPD)-related diseases, due to its inhibitory activity against phosphodiesterase 4 (PDE4) [16,17]. Here, PDE4A is linked to chronic obstructive pulmonary disease.