Butyric acid is one of the most abundant and important SCFAs in the gut due to its multiple effects, among which is its participation in energy homeostasis increasing the sensation of satiety and regulating appetite and energy intake [52], such as in carbohydrate homeostasis, favoring the secretion of GLP-1 and PYY in L cells, which can influence blood glucose and insulin response with improved insulin resistance [53,54]. The gene discussed is INS; the disease is Insulin resistance.