We are confident that the presence of Cx43 in small extracellular vesicles is not a phenomenon unique to hCMEC/D3 cells, since it was found in similar vesicles of other sources by Soares et al. [12], and we have found it in vesicles derived from other endothelial cells, glioblastoma cells, oligodendroglioma cells, and fibroblasts (Figure 3). The gene discussed is GJA1; the disease is glioblastoma.