In UC models induced by DSS, administration to C57BL/6 mice of γ-oryzanol (50 mg/Kg/day for 16 days), a mixture of phytosteryl ferulates derived from rice bran oil, mitigated clinical symptoms associated to UC and partially prevented colon shortening (~9%) and the pathophysiological activity during colonic inflammation through inhibition of NF-κB activation after 5 days of DSS at 3% (v/v) induction [24]. The gene discussed is NFKB1; the disease is colitis.