Similarly, β-sitosterol administration (10 or 20 mg/kg) during 3 days to C57BL/6 mice with colon inflammation induced by TNBS prevented partially colon shortening (~3.4%) and improved the pro-inflammatory status, reducing pro-inflammatory cytokine levels (IL-1β, TNF-α and IL-6) and MPO activity in colon tissue (~42%), with a concomitant inhibition of NF-κB translocation into the nucleus [17]. The gene discussed is IL6; the disease is colitis.