TNF and Insulin resistance: In steatohepatitis and insulin resistance murine models induced by high fat content diets, β-Cx administration (~2.5–7.5 mg/kg/day) lead to attenuation of lipotoxicity-induced inflammation, preventing hepatic tissue peroxidation (TBARS) and the macrophages activation [43], as well as the stimulation of antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) and inhibition of the expression of pro-inflammatory markers (NF-κB and TNFα) in liver [44].