In contrast, the protein level of RyR2-pS2808 in the DM group (1.51 ± 0.17, relative to control, N = 7) was higher than those in the control (N = 7, p < 0.05 and empagliflozin-treated DM groups (0.53 ± 0.04, relative to control, p < 0.005; N = 7). This evidence concerns the gene RYR2 and diabetes mellitus.