The protein expressions of SERCA2a (0.57 ± 0.06, relative to control, p < 0.005) and RyR2 (0.69 ± 0.09 relative to control, p < 0.05) in the DM group (N = 7) were downregulated, compared with those in control (N = 7) and empagliflozin-treated DM groups (0.98 ± 0.09; 1.09 ± 0.12, relative to control, N = 7, Figure 7). The gene discussed is RYR2; the disease is diabetes mellitus.