The major findings of the present study can be summarized as follows: (1) CFH and STAT4 expression levels were correlated in lung cell lines and human lung cancer tissues; (2) STAT4 regulated CFH expression by directly binding the CFH promoter as a transcription factor; (3) the SOCS family negatively regulated CFH expression by suppressing the STAT4 pathway; and (4) epigenetic gene regulation, such as methylation, did not influence the expression of the SOCS family but did regulate STAT4 expression in lung cancer. Here, CISH is linked to lung cancer.