VEGFA and neoplasm: In fact, GAMMs show typical hints of an alternative macrophage activation, as they can inhibit inflammation via transforming growth factor (TGF) β1, arginase 1 (ARG1), and interleukin 10 (IL-10) production and shape the tumor microenvironment through secretion of vascular endothelial growth factor (VEGF) and matrix metalloproteases (MP); meanwhile, they show classical macrophage activation aspects, such as the production of pro-inflammatory molecules (IL-1β, tumor necrosis factor, IL-6, and IL-12), along with the induction of T helper 1 (Th1)-mediated immune responses [54,55,56,57,58].