Apart from a long-term resident population of CD8+CD25+CD45RO+CD28+CD26L+CCR7+ memory T cells, CD8+CD3+ and CD4+CD3+ TILs were described in GBM, especially in fibrinogen-positive areas, where vessels are no longer watertight, and are positively associated with a longer clinical survival [69,70]. Here, CD4 is linked to glioblastoma.