These findings were further confirmed by the identification of CD133- and nestin-positive cells, as well as the expression of progenitor/stem-cell markers GD3 ganglioside and NG2 proteoglycan and angiogenesis-related factors (VEGF, VEGF receptors 1 and 2, Hypoxia-inducible factor-1α and -2α), in both GBM and in the peritumoral tissue, where this expression was also detected in apparently normal cells [8,12,13]. Here, NES is linked to glioblastoma.