For example, an autocrine induction of cellular proliferation was observed in chronic myeloid leukemia [236]) and in human gastric cancer [237,238] via phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) and MAPK/ERK signaling pathways [237]. The gene discussed is AKT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.