Furthermore, in the above mentioned own study, computer simulations suggested, and in vitro experiments confirmed, that in genetically heterogeneous melanoma tumors, genotoxic drug treatment favors selection of chemoresistant clones by amplifying the deregulation of the selected gene circuits, such as the E2F1-p73/DNp73-miR-205 circuit [75]. The gene discussed is E2F1; the disease is melanoma.