In the clinical setting, low serum Klotho concentrations in adult subjects without known risk factors for cardiovascular disease have been related to a reduced capacity of flow-mediated dilation of the brachial artery and higher values of epicardial fat thickness and carotid artery intima-media thickness, suggesting that Klotho deficiency may be an early predictor of subclinical atherosclerosis [27]. Here, KL is linked to cardiovascular disorder.