PPARG and hypertensive disorder: A possible mechanism for this effect might be the activation of SIRT1; our group previously showed that the RSV + QRC mixture reduces hypertension, IR, body fat, and dyslipidemia in the MS rat model, and these changes were associated with the overexpression of PPARγ, SIRT-1, and SIRT2 in intra-abdominal adipose tissue [24].