Furthermore, stimulation of HT-29 (human colon cancer cell line) and WiDr (colon adenocarcinoma line) cells with IL-36α and IL-36γ activate a signaling cascade through MyD88 adaptor protein complex (MyD88, TRAF6, IRAK1, and TAK1), phosphorylation of MAPKs and activation of NF-kB and AP-1 [109]. The gene discussed is MYD88; the disease is colon adenocarcinoma.