There is some indication that curcumin may influence NF-κB by preventing the diabetes-induced retinal activation of calcium/calmodulin-dependent protein kinase II (CAMKII) [27,74,75,76], a ubiquitous multifunctional protein kinase implicated in the regulation of the transcriptional activity of NF-κB [77]. This evidence concerns the gene NFKB1 and diabetes mellitus.