IGHE and Alzheimer disease: Vitamin D also regulates innate and adaptive immunity in a number of ways such as by encouraging mast cells to produce an anti-inflammatory cytokine IL-10, blocking the release of Th1 pro-inflammatory cytokines, preventing monocytes from expressing Toll-like receptors, reducing dendritic cell activity with lipopolysaccharides, and by cutting down the release of IgE, all of which hints that vitamin D is at least partially involved in AD and other inflammatory skin conditions [164] (Figure 5).