In addition to classic OSA cytokines (IL-6, VEGF, TGF-β, interferons, TNF-α, IL-2), new players have been identified in the emerging cytokine network (IL-15, IL-17, IL34, IL-8, CXCL12, fractalkine) providing meaningful information relevant to osteosarcoma immunotherapy [11]. This evidence concerns the gene CXCL8 and osteosarcoma.