This screen contained ~2500 genes and identified hits in the IFNγ response and antigen presentation pathways as expected, but also less understood hits such as PTPN2. From these two studies alone, the breadth of knowledge and the resources available to develop hypothesis-driven research about tumor cell influence on immune system response was significantly expanded and will continue to provide additional knowledge about these complex processes. The gene discussed is PTPN2; the disease is neoplasm.