Although there is no indication that pM27 directly affects the IFNβ enhanceosome [125], certain cells like myeloid dendritic cells (mDCs), but not plasmacytoid dendritic cells (pDCs), exhibit increased IFN-I secretion upon infection with M27-deficient (ΔM27)-MCMV as compared to a wt-MCMV infection [126]. The gene discussed is IFNB1; the disease is infection.