Sciacovelli et al. demonstrated that intracellular fumarate accumulation drives changes in EMT genes, such as zinc finger E-box binding homeobox (ZEB), snail family transcriptional repressor 1 (SNAI1) and vimentin (VIM), through inhibition of TETs and consequent anti-metastatic microRNA cluster downregulation, in murine renal carcinoma cells [142]. The gene discussed is SNAI1; the disease is renal carcinoma.