ADRB2 and cardiac hypertrophy: In previous studies in mice, the non-specific β-AR agonist isoproterenol (30 mg/kg/day for 1 week) induced cardiac hypertrophy by approximately 17% [67], while the β2-AR specific agonist CB (2 mg/kg/day for 4 weeks) also induced cardiac hypertrophy by approximately 17% [68], suggesting that hypertrophic response was similar to our study, even though the dose and treatment period were greater.