It is interesting to report that two of the remaining genes that do not appear associated to obesity traits in GeneRif are indeed involved in leptin pathways: BCL2L1, BCL2 like 1, part of the Leptin signaling pathway (WikiPathways); and NRG1, neuregulin 1, part of the Signaling by Leptin pathway (Reactome) and also associated to schizophrenia[44]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.