In general, the advanced tumors with higher stages intend to have a poorer prognosis and they are more likely to affect the nervous system.[8] Based on other reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we propose that the early diagnosis and treatment of both peripheral neuropathy and NHL may improve prognosis of patients. This evidence concerns the gene CD40LG and non-Hodgkin lymphoma.