CD5 and B-cell non-Hodgkin lymphoma: First, monoclonal autoantibodies (usually IgM paraprotein) produced by malignant transformation of the autoreactive B-cells, have the characteristics of natural autoantibodies[1,18] which directed against self and non-self antigens without antigenic stimulation of secretory CD5+ B-cells.[19] A patient was reported with a B-cell lymphoma producing autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b.