FCGR1A and Sepsis: We did not see reversal of some of these changes, such as HLA-DR percentage, following culture with zymosan, as has previously been seen with beta-glucan stimulation of LPS-trained monocytes in vitro.50 Lower HLA-DR and CD64 expression on monocytes have been associated with increased mortality following sepsis,29 and along with reduced stimulated cytokine production, mirror the changes seen in postsepsis immunoparalysis.