Specifically, for PKP2 the WES cohort demonstrated 78 unique affected positions, of which 3 (3.8% [2.4–5.3]) were shared with the 116 of the ARVC case cohort, whereas 51 (65.4% [61.8–69.0]) were shared with the 536 of the control cohort (p < 0.00001; Figure 4b). Here, PKP2 is linked to Arrhythmogenic right ventricular dysplasia.