Mef2c expression and MEF2C protein levels are increased in the myocardium of mice with angiotensin II induced cardiac hypertrophy, and MEF2C silencing by siRNA attenuates ventricular hypertrophy in an angiotensin II and aortic banding model of cardiac hypertrophy (42, 43). The gene discussed is AGT; the disease is Ventricular hypertrophy.