VEGFA and neoplasm: Indeed, the hypoxic conditions characteristic of the tumor environment induce both up-regulation of VEGFRs and gene expression of vascular endothelial growth factors (VEGFs) (Ferrara et al., 2003; Hoeben et al., 2004; Olsson et al., 2006; Carmeliet and Jain, 2011; Shibuya, 2013).