This lack of clarity is reflected in the differing approvals by governing bodies, with the FDA not approving ABCP for patients with EGFR activating mutations/ALK rearrangements, and other areas of the world (e.g., the European Medicines Agency) approving ABCP for patients with these genetic subsets of NSCLC. This evidence concerns the gene ABCG2 and non-small cell lung carcinoma.