Morel et al. summarized that the deficiency of SMARCB1, ARID1A, SMARCA4, and PBRM1, which constitute the chromatin remodeling complex SWI/SNF subunit, led to an EZH2 oncogenic dependence in tumor cells, and pharmacological EZH2 inhibitors such as tazemetostat induced dramatic tumor shrinkage in these subunits-deficient tumors (66). This evidence concerns the gene PBRM1 and neoplasm.