Upon recognition of the target tumor antigen, CAR T cell activation and expansion at a tremendous rate can result in cytokine release syndrome (CRS), a common side effect of CAR T cell therapy that is characterized by markedly elevated soluble IL2, IL6, IL10, IFNg, as well as elevated CRP, ferritin and decreased fibrinogen (8). The gene discussed is IL6; the disease is congenital rubella syndrome.