Based upon these and other findings, clinical trials using the CD16VV UIR are currently underway for the treatment of non-Hodgkin's lymphoma (CD20+), HER2-positive cancer (trastuzumab) or multiple myeloma (SEA-BCMA) (Unum: NCT02776813, NCT03189836, NCT03266692, NCT03680560). Here, ERBB2 is linked to cancer.