In this study, we analyzed ncRNA expression profiles of 80 glioma samples from GEO and identified a ncRNA‐based prognostic signature composed of the weighted expressions of USP46‐AS1, PON2 and LOC441179; based on this, glioma samples could be divided into high‐ and low‐risk groups with significantly different OS. Here, PON2 is linked to central nervous system cancer.