GRK6 and metastatic malignant neoplasm in the lymph nodes: An MSP assay of 54 LADC tissues showed GRK6 promoter methylation, including hypermethylation and partial methylation, in 42 out of 54 LADC patients and was associated with pathology grade (P = 0.024), whereas no correlation was found between the GRK6 promoter methylation level and age, gender, smoking status, staging, and lymph node metastasis (Table 1).