31 reported that C/EBPα suppresses hepatocellular cancer metastasis by downregulating the epidermal growth factor receptor/β‐catenin signaling pathway, which mediates EMT. Another recent study conducted by Lu et al. 30 suggested that C/EBPα inhibits cell migration and invasion by suppressing EMT in LADC cells. In our study, C/EBPα regulated EMT and MMPs through transcription regulation of GRK6, which is a novel mechanism of C/EBPα as a tumor suppressor in LADC. This evidence concerns the gene CEBPA and neoplasm.