There is evidence that the etiology of SLE might relate to epigenetic dysregulation of AIM2. A high-throughput analysis of CpG-containing promoters for various genes revealed significant differences in AIM2 promoter methylation (p = 0.01) in monozygotic twin pairs disconcordant for SLE (Javierre et al., 2009). Here, AIM2 is linked to systemic lupus erythematosus.