The western blot experiment showed that the overexpression of survivin negatively correlates with the expression of Cleaved Caspase-3 in CVB3-infected NRC and the murine model of CVB3-induced myocarditis, indicating that the overexpression of survivin may protect NRC from CVB3-induced apoptosis by abolishing the activation of caspase-3. The gene discussed is BIRC5; the disease is myocarditis.