Different types of proteases are involved in ECM degradation and remodeling, including members of the matrix metalloproteinase (MMP) family, their inhibitors (tissue inhibitors of metalloproteinases (TIMP)), urokinase-type plasminogen activator (uPA) and its receptor, and cathepsin B. Increased expression of these proteases positively correlates with invasion potential and glioma grade [7, 8]. Here, PLAU is linked to central nervous system cancer.