Receiver operating characteristic (ROC) curve analysis of diagnostic value of iron-status biomarkers in distinguishing between IDA (sideropenic anemia) and ACD (ESRD patients) was shown excellent diagnostic properties for hepcidin-25, ferritin, transferrin saturation, and MCV, with area under the curve (AOC) > 0.9 (Figure 1). The gene discussed is HAMP; the disease is granular corneal dystrophy type II.