In our study we have evaluated in AD patients, both in ApoE4 (ε4) carriers and non-carriers, three plasmatic OS markers (Plasmatic soluble receptor for advanced glycation end products – sRAGE - levels, plasma antioxidant total defenses, by lag-time method, and plasmatic ROS levels in order to evaluate a possible association between these OS markers and ApoE4 (ε4) carrier status. The gene discussed is APOE; the disease is Alzheimer disease.