Increasing evidence indicates that miRNAs can affect the progress of DN by regulating various signal pathways in the pathogenesis of DN, such as TGF-β, Akt, NF-B, etc. MiRNAs can also be highly specific in the body fluids of patients, and its degree of change is often more sensitive than the currently commonly used clinical indicators (Such as urine protein). Here, AKT1 is linked to liver dysplastic nodule.