Among the studies, miR-133b, miR-345, miR-33, miR-126, miR-217, and miR-15b were significantly related to HbAc1 in DN patients in the studies by Eissa et al. [12], Bijkerk et al. [17], and Al-Kafaji et al. [14] (P<0.05). The gene discussed is ADCY8; the disease is liver dysplastic nodule.