EGFR and cancer: These three clusters involved the already described genes EGFR, CDKN2A, and PTEN. However, besides these loci, GO-term enrichment analysis pointed out defects in other genes, with similar CNA profiles among GBM/GSC couples, encompassing pathways essential for the development and progression of cancer, such as pathway related to angiogenesis, as well as pathways related to the immune system regulation.