These three clusters involved the already described genes EGFR, CDKN2A, and PTEN. However, besides these loci, GO-term enrichment analysis pointed out defects in other genes, with similar CNA profiles among GBM/GSC couples, encompassing pathways essential for the development and progression of cancer, such as pathway related to angiogenesis, as well as pathways related to the immune system regulation. The gene discussed is PTEN; the disease is cancer.