Furthermore, several cancer related pathways were also significantly enriched in high-risk subgroup, including “signaling by Wnt,” “mismatch repair,” “p53 dependent G1 DNA damage response,” “SCF β-TRCP mediated degradation of EMI1,” “SCFSKP2 mediated degradation of P27/P21,” “FOXMI pathway,” “BARD1 pathway,” and “ARF6 downstream pathway,” which were already proved involved in the oncogenesis and progression of BRCA. Here, FBXO5 is linked to cancer.