For instance, CD44v isoform, an alternative splicing variant of CD44 containing v8–v10 exons, was convinced to drive tumor progression and metastasis by promoting BRCA stemness via activating the PDGFRβ/Stat3 cascade and PFKFB4-mediated glucose metabolism despite tumor-suppressing genetic origin (Gao et al., 2018; Zhang et al., 2019). This evidence concerns the gene PFKFB4 and neoplasm.