GRIN1 and major depressive disorder: In addition to the previous discussed Weder et al. study that implicated the neurotransmitter gene glutamate receptor, ionotropic N-methyl-D-aspartate 1 (GRIN1) in ELA/MDD, one gene, 5-HT2A, has been explored in the prefrontal cortex (PFC) for its potential contribution to ELA related MDD and suicide (Du et al., 2000, 2001; De Luca et al., 2007, 2009).