Once more, although this treatment was able to induce Treg cells and improve the unbalanced ratio between CD4+ CD25- to Treg cells during the chronic phase of the infection, the fact that 3-HK is only partially efficient in controlling the parasitemia and unable to eradicate the parasite (32), shifted the host-parasite balance to the parasite replication. This evidence concerns the gene CD4 and parasitic infectious disease.