Moreover, it is worth noting that IL-1, IL-8, and IL17A all play important roles in smooth muscle contraction and contribute to the impaired elasticity of the pulmonary tissues through bronchio/alveolar constriction (50, 51), likely resulting in the increased tachypnea and airway obstruction (Figures 1A,B). The gene discussed is CXCL8; the disease is Airway obstruction.