TGM2 and celiac disease: Similarly, and maybe even more confusing, is the fact that celiac disease patients develop IgA anti-tissue transglutaminase antibodies resulting in infiltration of mainly mononuclear cells in the intestinal tract, while in dermatitis herpetiformis (skin manifestation of celiac disease) binding of IgA autoantibodies to epidermal transglutaminase results in neutrophil recruitment (181).