Moreover, CKB (creatine kinase B-type), which was highly over-expressed by ZIKV infection, is crucial in maintaining ion homeostasis in the brain, and glutamate uptake in neurotransmitter trafficking between astrocytes and oligodendrocytes and between axons and the contact points with the nodes of Ranvier (Steen et al., 2010). This evidence concerns the gene CKB and Zika virus infectious disease.