Combining maternal risk factors, biochemical markers such as ADAM12 (A Disintegrin and Metalloprotease-12) and placental protein-13, plus abnormal uterine artery waveforms for the prediction of late-onset IUGR (with a false positive rate of 5%), provides a sensitivity of 61% for IUGR at <37 weeks but unfortunately only 32% for IUGR at >37 weeks (166). The gene discussed is ADAM12; the disease is fetal growth restriction.