These five genes are GPX7, NUDT14, LBH, ZCCHC10, and DENND2A. Although we have not replicated published findings on IS/PD risk genes, these five shared genes we identified here have been studied extensively, and many experiments show that they play important roles in the pathogenesis of IS and PD (50, 51). Here, NUDT14 is linked to Parkinson disease.