Furthermore, in human postmortem studies, lower hippocampal 5-HT1A mRNA is demonstrated in MDD subjects, with death by accident, assault, suicide, or cardiac causes (Lopez et al., 1998) and reduced 5-HT1A receptors in amygdala and hippocampus in suicide completers (Cheetham et al., 1990). The gene discussed is HTR1A; the disease is major depressive disorder.