However, although SNS or fluoxetine treatment did not significantly mitigate the 5HT1A receptor-pPKA substrate-CREB-pCREB-BDNF pathway in the hippocampus of MS rats, compared with the model group, medium and high SNS doses partly restored the expression of 5-HT1A receptor, CREB, pCREB, and BDNF (Figure 8). Here, CREB1 is linked to myeloid sarcoma.