Sun et al. (2011) found that S1103Y cardiac sodium channel variant was associated with ICD events in blacks with heart failure (hazard ratio:4.33). Based on the functional characterization of SCN5A R1193Q in the present study, we propose that SCN5A R1193Q is a risk factor for arrhythmia in Asian populations despite without evidence of epidemiological study. More recently, Makarawate et al. (2017) reported that SCN5A R1193Q polymorphism was associated with appropriate ICD shock therapy in symptomatic BrS patients with ICD treatment (hazard ratio:10.56) that is consistent with our hypothesis. The gene discussed is SCN5A; the disease is heart failure.