CACNA1C and Prolonged QT interval: As a consequence, functional alterations in Cav1.2 channels mainly due to CACNA1C gene mutations lead to cardiac arrhythmic disorders such as atrial fibrillation, long QT syndrome and conduction defects, as well as structural cardiac disorders such as cardiomyopathies and congenital heart defects (Benitah et al., 2010).